Past Meeting: Konigswinter, Germany 2006

 

Main Program Oral Presentations


  • Drug side effects to the eye - current topics and future developments?
  • Ocular pharmacodynamics
  • Framework and the guidelines for ocular drug safety on a European level (EU / ICH)
  • Detecting pharmacological and toxicological effects of drugs on retinal function
  • Multi-electrode array recording: a technique to assess pharmacological effects on retinal information processing by recording ganglion cell light responses in the ex vivo retina
  • Photopics ERGs in selected animal species : evidence associating a post B-wave negativity with the tapetum lucidum
  • The role of ophthalmic pathology in ocular toxicology
  • Ultraviolet radiation toxicity in the eye
  • Testing for phototoxicity of drugs
  • Medicinal product, medical device, or dietary supplement: problems with clinical trials in ophthalmology
  • Ocular toxicity: The significance of preclinical data for the authorisation of clinical trials
  • Ocular side-effects of ophthalmics / non-ophthalmics - How to investigate toxic effects?
  • Routine and specific ocular examinations in non clinical safety studies
  • Nonclinical assessment of ocular toxicity and pharmacokinetics of Pegaptanib sodium (Macugen)
  • Ocular cells in culture - a test system for elucidation of toxic effects to the posterior eye segment
  • The COLIPA research programme for the development of in vitro alternatives methods for eye irritation: update,
  • Organotypic 3D cell culture models of the cornea for in-vitro permeation studies
  • Ocular examination and OCT of the cat eye and retina
  • Retinal safety of Pradofloxacin in cats - an electrophysiological study
  • Recovery of the scotopic b-wave of the electroretinogram after light exposure in mice
  • Safety issues for drug development with intraocular applications
  • Intraocular application of drugs for treatment of diabetic maculopathy
  • The Ex-Vivo Eye Irritation Test (EVEIT), hazard evaluation on chemicals on the eye including repeated exposure and recovery
  • Rat-specific opacities induced by anticholinergics
  • Ocular evaluation of potential ocular toxicity in regulatory non clinical safety studies
  • Toxicological aspects of retinal ultrastructural pathology
  • Evaluation of toxic effects of ultravioletB induced apoptosis in retinal ganglion cells
  • Electrophysiologic assessment of intraocular Bevacizumab (AvastinTM) toxicity
  • Evidence for transport of Bevacizumab (Avastin) through the retina in monkeys
  • Ocular angiogenesis in ischemic proliferative retinopathy (AvastinTM)
  • Ophthalmic product development: an assessment of FDA and EMEA clinical requirements
  • How many patients? How many animals? Lessons from biometry
  • "Aspects and requirements of clinical studies - the clinicians view"
  • "Detection of unknown adverse events in clinical practice - How to become aware of existing risks"
  • Adverse drug reactions in ophthalmology
  • Relationship between crystalline lens injury by millimeter wave exposure and aqueous humor convection
  • Increased oxygen in the vitreous cavity is a major risk factor for nuclear cataract formation in humans
  • NAT2 and UGT1A1 allele frequencies in glaucoma or cataract patients compared to controls
  • Relevance of ocular toxicity for clinical therapy
  • Use of in vitro data and (Q)SARs for classifying eye irritating chemicals in the EU - experience at the BfR

Poster presentations


  • ESTP CD-ROM announcement: glossary and photo guide on clinical and histopathological ocular findings in laboratory animalS
  • Cytotoxic effect of rose Bengal and lissamine green on cultured rabbit corneal cell line
  • Effects of antiglaucoma drugs on leukotriene C4 release after rat mast cell activation
  • Effects of antiglaucoma drugs on TNF-α release after rat mast cell activation
  • Investigating structure-activity relationships for non-irritant ocular toxicity
  • Effects of Indocyanine green on cultured rat retinal ganglion cells in vitro
  • Tonometry with the applanation tonometer Ocuton A® in normotensive Beagle dogs
  • Region-specific expression of drug metabolizing enzymes in the rat ocular tissues
  • The study of synthetic retinal peptide toxic effect on eye orbit tissues in case of its parabulbar administration